CUL5

Across TCGA patient cohorts, CUL5 protein abundance is significantly associated with the RNA expression of many other genes, with 8,985 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CUL5-associated genes across cancer lineages are ZBTB44, IFT46, and C11orf1. Each is linked with CUL5 in more than 6 cancer types. Because this analysis shows association rather than direction, both CUL5-to-partner and partner-to-CUL5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CUL5 versus ZBTB44 in BRCA, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL5→partner) and Y-score (partner→CUL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZBTB44 →	+0.846	+0.301	<.001	<.001	3	7
BRCA	IFT46 →	+0.577	+0.205	<.001	<.001	3	7
OV	C11orf1 →	+0.727	+0.260	<.001	<.001	3	7
UCEC	CENPF →	-1.149	-0.207	<.001	<.001	3	6
LUAD	ACAD8 →	+0.635	+0.125	<.001	.001	3	6
CCRCC	VPS11 →	+0.438	+0.220	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,985 associations by consensus.

CUL5 vs ZBTB44 — BRCA

Explore this scatter interactively →