CUL5

Across TCGA patient cohorts, CUL5 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUL5-associated genes across cancer lineages are ASNS, eEF2, and A-Raf_pS299. Each is linked with CUL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CUL5-to-partner and partner-to-CUL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CUL5-low versus CUL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL5→partner) and Y-score (partner→CUL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.401	+2.169	<.001	.003	3	3
UCEC	eEF2 →	+0.275	+2.000	.016	.029	3	2
UCEC	A-Raf_pS299 →	-0.126	-2.169	<.001	.003	3	2
UCEC	ERK2 →	+0.174	+1.584	.004	.017	3	2
UCEC	Mre11 →	-0.057	-2.088	.035	.016	3	2
UCEC	p53 →	-0.264	-1.906	.033	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ASNS by CUL5 expression — UCEC

Explore this box plot interactively →