CUL5

Across TCGA cell cohorts, CUL5 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CUL5-associated genes across cancer lineages are CRYBA1, OVCH2, and CCR8. Each is linked with CUL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CUL5-to-partner and partner-to-CUL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBA1 grouped by CUL5-low versus CUL5-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL5→partner) and Y-score (partner→CUL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CRYBA1 →	+0.047	+3.584	<.001	.007	3	1
BLOOD_Myeloma	OVCH2 →	+0.011	+3.285	.001	.009	3	1
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	BHLHA9 →	+0.036	+5.977	<.001	.001	3	1
SOFT_TISSUE	GOLGA6L6 →	+0.013	+5.369	<.001	.004	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.017	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

CRYBA1 by CUL5 expression — BLOOD_Myeloma

Explore this box plot interactively →