CUL4B

Across TCGA pan-cancer cohorts, CUL4B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CUL4B data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CUL4B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CUL4B expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where CUL4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.506	0.928	<.001	25	view →
LUAD	DFS	Quartile	II,III,IV	0.174	0.836	.001	17	view →
HNSC	OS	Median	All	0.380	1.000	.008	12	view →
UCEC	OS	Median	All	0.901	1.000	.006	8	view →
PDAC	OS	Median	All	0.276	0.527	.005	7	view →
LSCC	OS	Median	II,III,IV	1.000	0.907	.026	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CUL4B–CCRCC (DFS)

Open the CCRCC breakdown →