CUL3

Across TCGA patient cohorts, CUL3 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,820 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CUL3-associated proteins across cancer lineages are ILKAP, RNF25, and SND1. Each is linked with CUL3 in more than 5 cancer types. Because this analysis shows association rather than direction, both CUL3-to-partner and partner-to-CUL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CUL3 versus ILKAP in LSCC, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL3→partner) and Y-score (partner→CUL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ILKAP →	+0.321	+0.436	<.001	<.001	3	6
OV	RNF25 →	+0.277	+0.427	.003	<.001	3	5
BRCA	SND1 →	-0.233	-0.403	<.001	<.001	3	4
LUAD	SDF2L1 →	-0.396	-0.476	<.001	<.001	3	4
HNSC	LANCL1 →	+0.329	+0.593	<.001	<.001	3	4
GBM	MLKL →	-0.490	-0.240	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,820 associations by consensus.

CUL3 vs ILKAP — LSCC

Explore this scatter interactively →