CUL3

Across TCGA patient cohorts, CUL3 protein abundance is significantly associated with the RNA expression of many other genes, with 16,709 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CUL3-associated genes across cancer lineages are COPS8, MFF, and NDUFA10. Each is linked with CUL3 in more than 6 cancer types. Because this analysis shows association rather than direction, both CUL3-to-partner and partner-to-CUL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CUL3 versus COPS8 in OV, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL3→partner) and Y-score (partner→CUL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COPS8 →	+0.392	+0.220	<.001	<.001	3	7
OV	MFF →	+0.455	+0.318	<.001	<.001	3	6
OV	NDUFA10 →	+0.476	+0.190	<.001	.006	3	5
OV	RETREG2 →	+0.467	+0.211	<.001	<.001	3	5
OV	PPP1R7 →	+0.333	+0.176	.002	.001	3	4
OV	EIF4E2 →	+0.352	+0.209	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,709 associations by consensus.

CUL3 vs COPS8 — OV

Explore this scatter interactively →