CUL3

Across TCGA patient cohorts, CUL3 mutation is significantly associated with the RNA expression of many other genes, with 6,102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUL3-associated genes across cancer lineages are PANX2, MED9, and CHAF1A. Each is linked with CUL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CUL3-to-partner and partner-to-CUL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PANX2 grouped by CUL3-low versus CUL3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL3→partner) and Y-score (partner→CUL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PANX2 →	+1.747	+3.459	<.001	.005	3	4
HNSC	MED9 →	+0.528	+3.459	<.001	.005	3	4
UCEC	CHAF1A →	+0.801	+3.758	<.001	<.001	3	4
HNSC	UGT1A4 →	+0.075	+3.396	.002	<.001	3	4
HNSC	DHRS11 →	+0.567	+3.374	.002	.004	3	4
KIRP	OSGIN1 →	+2.043	+3.185	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,102 associations by consensus.

PANX2 by CUL3 expression — HNSC

Explore this box plot interactively →