CUL3

Across TCGA cell cohorts, CUL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,844 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CUL3-associated GO terms across cancer lineages are Embryonic cleavage, Mitotic sister chromatid cohesion, and Sister chromatid cohesion. Each is linked with CUL3 in more than 12 cancer types. Because this analysis shows association rather than direction, both CUL3-to-partner and partner-to-CUL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Embryonic cleavage grouped by CUL3-low versus CUL3-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL3→partner) and Y-score (partner→CUL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Embryonic cleavage →	+0.252	+0.721	<.001	<.001	3	13
OESOPHAGUS	Mitotic sister chromatid cohesion →	+0.118	+0.464	<.001	.009	3	12
OESOPHAGUS	Sister chromatid cohesion →	+0.121	+0.518	.008	.004	3	11
UPPER_AERODIGESTIVE_TRACT	Centrosome duplication →	+0.094	+0.640	.002	<.001	3	11
OESOPHAGUS	Protein localization to condensed chromosome →	+0.162	+0.528	<.001	.002	3	11
SOFT_TISSUE	Regulation of chromosome condensation →	+0.220	+0.680	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,844 associations by consensus.

Embryonic cleavage by CUL3 expression — KIDNEY

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