CUL3

Across TCGA cell cohorts, CUL3 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CUL3-associated genes across cancer lineages are OR2T6, KRT71, and TAS2R38. Each is linked with CUL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CUL3-to-partner and partner-to-CUL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T6 grouped by CUL3-low versus CUL3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL3→partner) and Y-score (partner→CUL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR2T6 →	+0.035	+5.029	<.001	.006	3	1
BLOOD_Lymphoma	KRT71 →	+0.009	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	TAS2R38 →	+0.169	+4.350	<.001	.005	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PFN3 →	+0.169	+4.467	<.001	.004	3	1
LARGE_INTESTINE	IQCF6 →	+0.311	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR2T6 by CUL3 expression — LUNG_SCLC

Explore this box plot interactively →