CUL2

Across TCGA patient cohorts, CUL2 protein abundance is significantly associated with the RNA expression of many other genes, with 14,784 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CUL2-associated genes across cancer lineages are MASTL, YME1L1, and UPF2. Each is linked with CUL2 in more than 7 cancer types. Because this analysis shows association rather than direction, both CUL2-to-partner and partner-to-CUL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CUL2 versus MASTL in HNSC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL2→partner) and Y-score (partner→CUL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MASTL →	+0.759	+0.225	.002	<.001	3	8
HNSC	YME1L1 →	+0.875	+0.228	.007	<.001	3	8
BRCA	UPF2 →	+0.442	+0.201	.004	.002	3	8
HNSC	GTPBP4 →	+0.772	+0.198	.001	<.001	3	7
HNSC	MTPAP →	+0.680	+0.194	.004	<.001	3	7
LUAD	CCNY →	+0.543	+0.199	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,784 associations by consensus.

CUL2 vs MASTL — HNSC

Explore this scatter interactively →