CUL2

Across TCGA patient cohorts, CUL2 mutation is significantly associated with the RNA expression of many other genes, with 2,635 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUL2-associated genes across cancer lineages are NF1P2, CYCSP35, and CCL4. Each is linked with CUL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CUL2-to-partner and partner-to-CUL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF1P2 grouped by CUL2-low versus CUL2-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL2→partner) and Y-score (partner→CUL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NF1P2 →	+0.028	+5.584	<.001	.003	3	2
GBM	CYCSP35 →	+0.272	+5.352	<.001	.005	3	2
UCEC	CCL4 →	+0.654	+2.021	.003	<.001	3	2
BRCA	RNU1-154P →	+0.279	+5.347	<.001	.006	3	2
SKCM	IFNA21 →	+0.084	+4.052	<.001	.005	3	2
UCEC	SLC7A11 →	+0.875	+2.595	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,635 associations by consensus.

NF1P2 by CUL2 expression — GBM

Explore this box plot interactively →