CUL2

Across TCGA cell cohorts, CUL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,686 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CUL2-associated GO terms across cancer lineages are Negative regulation of beige fat cell differentiation, Positive regulation of mitochondrial ATP synthesis coupled electron transport, and Protein localization to kinetochore. Each is linked with CUL2 in more than 13 cancer types. Because this analysis shows association rather than direction, both CUL2-to-partner and partner-to-CUL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of beige fat cell differentiation grouped by CUL2-low versus CUL2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL2→partner) and Y-score (partner→CUL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of beige fat cell differentiation →	+0.211	+1.093	<.001	<.001	3	14
OESOPHAGUS	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.144	+0.910	<.001	.002	3	14
STOMACH	Protein localization to kinetochore →	+0.127	+0.777	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.115	+0.983	.003	.002	3	13
OESOPHAGUS	Protein localization to condensed chromosome →	+0.160	+0.698	<.001	.004	3	13
OESOPHAGUS	Protein localization to chromosome →	+0.091	+0.740	.001	.008	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,686 associations by consensus.

Negative regulation of beige fat cell differentiation by CUL2 expression — LIVER

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