CUEDC2

Across TCGA patient cohorts, CUEDC2 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUEDC2-associated genes across cancer lineages are p27, ER-alpha, and AR. Each is linked with CUEDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CUEDC2-to-partner and partner-to-CUEDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27 grouped by CUEDC2-low versus CUEDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUEDC2→partner) and Y-score (partner→CUEDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27 →	+0.294	+3.000	.010	.036	3	2
UCEC	ER-alpha →	+0.866	+3.321	.044	.010	3	1
UCEC	AR →	+0.548	+2.999	.005	.035	3	1
UCEC	Caspase-8 →	-0.275	-3.321	.037	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

p27 by CUEDC2 expression — UCEC

Explore this box plot interactively →