Across TCGA patient cohorts, CTXN3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTXN3-associated genes across cancer lineages are C-Raf, EGFR, and eIF4E. Each is linked with CTXN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTXN3-to-partner and partner-to-CTXN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTXN3→partner) and Y-score (partner→CTXN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.200	+2.321	<.001	.006	3	2
UCEC	EGFR →	-0.191	-1.807	.003	.027	3	1
UCEC	eIF4E →	+0.189	+3.335	.030	.005	3	1
UCEC	GAPDH →	+0.503	+3.169	.023	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.496	+3.179	.018	.010	3	1
UCEC	MEK1 →	+0.563	+3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

CTXN3 survival (RNA) · tumor vs normal (RNA) · all CTXN3 data types