CTXN2

Across TCGA patient cohorts, CTXN2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTXN2-associated genes across cancer lineages are ASNS, 14-3-3_beta, and eIF4G. Each is linked with CTXN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTXN2-to-partner and partner-to-CTXN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CTXN2-low versus CTXN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTXN2→partner) and Y-score (partner→CTXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.342	+2.000	.016	.030	3	2
UCEC	14-3-3_beta →	-0.095	-2.295	.016	.033	3	1
UCEC	eIF4G →	+0.253	+1.584	.038	.036	3	1
UCEC	A-Raf_pS299 →	-0.190	-3.906	<.001	<.001	3	1
UCEC	ERK2 →	+0.235	+2.000	.001	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.113	-2.105	.020	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ASNS by CTXN2 expression — UCEC

Explore this box plot interactively →