CTXN1

Across TCGA pan-cancer cohorts, CTXN1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CTXN1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CTXN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CTXN1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

THCA, KIRP, and LIHC are the cancer types where CTXN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTXN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+2.875	<.001	11	view →
KIRP	All	III,IV	+1.852	<.001	9	view →
LIHC	All	II,III,IV	+0.710	<.001	9	view →
KICH	Female	II,III,IV	−3.007	<.001	8	view →
HNSC	Male	III,IV	+2.112	<.001	8	view →
KIRC	All	II,III,IV	−0.859	<.001	7	view →
BRCA	All	III,IV	+2.063	<.001	6	view →
CHOL	Male	All	+4.415	<.001	3	view →
READ	Female	All	−2.522	.014	2	view →
BLCA	Male	IV	−2.465	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CTXN1–THCA

Open the THCA breakdown →