CTU2

Across TCGA patient cohorts, CTU2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTU2-associated genes across cancer lineages are 14-3-3_beta, p62 Lck ligand, and Annexin-1. Each is linked with CTU2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTU2-to-partner and partner-to-CTU2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CTU2-low versus CTU2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTU2→partner) and Y-score (partner→CTU2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.136	-2.308	.006	.036	3	1
UCEC	p62 Lck ligand →	+0.512	+3.179	.001	.010	3	1
UCEC	Annexin-1 →	+0.774	+2.827	.003	.035	3	1
UCEC	eIF4E →	+0.293	+3.459	.005	.005	2	1
UCEC	ERK2 →	+0.217	+2.321	.025	.035	1	1
UCEC	MEK1 →	+0.523	+3.459	.004	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

14-3-3_beta by CTU2 expression — UCEC

Explore this box plot interactively →