CTTNBP2NL

Across TCGA patient cohorts, CTTNBP2NL mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTTNBP2NL-associated genes across cancer lineages are PDCD4, 14-3-3_beta, and EGFR. Each is linked with CTTNBP2NL in more than 1 cancer types. Because this analysis shows association rather than direction, both CTTNBP2NL-to-partner and partner-to-CTTNBP2NL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by CTTNBP2NL-low versus CTTNBP2NL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTTNBP2NL→partner) and Y-score (partner→CTTNBP2NL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.533	-1.925	.001	.005	3	2
UCEC	14-3-3_beta →	-0.077	-1.847	.033	.049	3	1
UCEC	EGFR →	-0.212	-2.807	<.001	.003	3	1
UCEC	A-Raf_pS299 →	-0.135	-1.807	.001	.025	3	1
UCEC	ERK2 →	+0.195	+2.459	.004	.018	3	1
UCEC	FoxM1 →	+0.215	+1.584	.021	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PDCD4 by CTTNBP2NL expression — UCEC

Explore this box plot interactively →