CTTN

Across TCGA patient cohorts, CTTN mutation is significantly associated with the RNA expression of many other genes, with 2,828 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTTN-associated genes across cancer lineages are MELK, ORC6, and MASTL. Each is linked with CTTN in more than 2 cancer types. Because this analysis shows association rather than direction, both CTTN-to-partner and partner-to-CTTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MELK grouped by CTTN-low versus CTTN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTTN→partner) and Y-score (partner→CTTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MELK →	+0.749	+3.098	<.001	<.001	3	3
UCEC	ORC6 →	+0.652	+2.180	<.001	<.001	3	3
UCEC	MASTL →	+0.404	+1.893	.009	<.001	3	3
READ	RPL23AP4 →	+0.127	+5.039	<.001	.008	3	2
SARC	RN7SL509P →	+0.190	+6.977	<.001	<.001	3	2
SARC	MIR4295 →	+0.525	+5.954	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,828 associations by consensus.

MELK by CTTN expression — UCEC

Explore this box plot interactively →