CTTN

Across TCGA patient cohorts, CTTN mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTTN-associated genes across cancer lineages are eIF4E, Cyclin-B1, and 4E-BP1. Each is linked with CTTN in more than 3 cancer types. Because this analysis shows association rather than direction, both CTTN-to-partner and partner-to-CTTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CTTN-low versus CTTN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTTN→partner) and Y-score (partner→CTTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.192	+2.137	.007	.001	3	3
UCEC	Cyclin-B1 →	+0.686	+2.906	<.001	.001	2	4
LUAD	4E-BP1 →	+0.433	+3.000	.008	.036	2	3
UCEC	EGFR_pY1068 →	-0.213	-1.514	.012	.015	3	2
UCEC	A-Raf_pS299 →	-0.130	-3.321	.001	.009	3	2
UCEC	Notch1 →	+0.124	+1.247	.009	.045	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

eIF4E by CTTN expression — UCEC

Explore this box plot interactively →