CTTN

Across TCGA cell cohorts, CTTN mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CTTN-associated genes across cancer lineages are GIMD1, ACER1, and XAGE2. Each is linked with CTTN in more than 1 cancer types. Because this analysis shows association rather than direction, both CTTN-to-partner and partner-to-CTTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GIMD1 grouped by CTTN-low versus CTTN-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTTN→partner) and Y-score (partner→CTTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GIMD1 →	+0.025	+3.232	<.001	.008	3	2
LARGE_INTESTINE	ACER1 →	+0.063	+2.938	.008	.003	3	2
LUNG_SCLC	XAGE2 →	+0.552	+3.256	<.001	.005	3	1
LUNG_SCLC	LCE3D →	+0.054	+3.232	<.001	.008	3	1
LUNG_SCLC	SIGLEC7 →	+0.488	+3.869	.002	.002	3	1
LUNG_SCLC	PRND →	+0.025	+3.906	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

GIMD1 by CTTN expression — LUNG_SCLC

Explore this box plot interactively →