CTSZ

Across TCGA pan-cancer cohorts, CTSZ mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CTSZ’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CTSZ mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CTSZ is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

HNSC, COAD, and LSCC are the cancer types where CTSZ tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTSZ mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.313	<.001	8	view →
COAD	Female	III,IV	−0.605	<.001	7	view →
LSCC	Male	II,III,IV	−0.452	<.001	7	view →
PDAC	Female	All	+0.703	<.001	6	view →
CCRCC	Male	III,IV	−0.458	<.001	6	view →
OV	All	All	+0.326	.011	2	view →
LUAD	Male	III,IV	−0.322	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CTSZ–HNSC

Open the HNSC breakdown →