CTSS

Across TCGA patient cohorts, CTSS protein abundance is significantly associated with the RNA expression of many other genes, with 18,401 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CTSS-associated genes across cancer lineages are SLAMF7, ABI3, and GPR174. Each is linked with CTSS in more than 9 cancer types. Because this analysis shows association rather than direction, both CTSS-to-partner and partner-to-CTSS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTSS versus SLAMF7 in UCEC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSS→partner) and Y-score (partner→CTSS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLAMF7 →	+1.668	+0.673	<.001	<.001	3	10
GBM	ABI3 →	+0.910	+0.632	<.001	<.001	3	9
HNSC	GPR174 →	+1.259	+0.527	<.001	<.001	3	9
HNSC	CD3G →	+1.123	+0.504	<.001	<.001	3	9
HNSC	PYHIN1 →	+1.111	+0.497	<.001	<.001	3	9
UCEC	CD3D →	+1.873	+0.497	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,401 associations by consensus.

CTSS vs SLAMF7 — UCEC

Explore this scatter interactively →