CTSS

Across TCGA patient cohorts, CTSS mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSS-associated genes across cancer lineages are Macrophages, mv Endothelial cells, and Basophils. Each is linked with CTSS in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSS-to-partner and partner-to-CTSS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macrophages grouped by CTSS-low versus CTSS-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSS→partner) and Y-score (partner→CTSS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Macrophages →	+0.031	+3.288	.005	.041	3	1
UCEC	mv Endothelial cells →	-0.023	-3.169	.040	.019	3	1
UCEC	Basophils →	+0.163	+2.459	.047	.020	3	1
UCEC	Class-switched memory B-cells →	-0.061	-3.584	.026	.003	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Macrophages by CTSS expression — COAD

Explore this box plot interactively →