CTSS

Across TCGA cell cohorts, CTSS RNA expression is significantly associated with the go_rna of many other GO terms, with 5,710 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CTSS-associated GO terms across cancer lineages are Basement membrane disassembly, Activation of innate immune response, and Innate immune response-activating signaling pathway. Each is linked with CTSS in more than 19 cancer types. Because this analysis shows association rather than direction, both CTSS-to-partner and partner-to-CTSS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Basement membrane disassembly grouped by CTSS-low versus CTSS-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSS→partner) and Y-score (partner→CTSS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Basement membrane disassembly →	+1.979	+3.359	<.001	<.001	3	20
PANCREAS	Activation of innate immune response →	+0.067	+2.860	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Innate immune response-activating signaling pathway →	+0.085	+2.940	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Pattern recognition receptor signaling pathway →	+0.084	+2.809	<.001	<.001	3	16
LARGE_INTESTINE	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.214	+2.704	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of antigen processing and presentation →	+0.248	+2.823	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,710 associations by consensus.

Basement membrane disassembly by CTSS expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →