CTSO

Across TCGA patient cohorts, CTSO protein abundance is significantly associated with the RNA expression of many other genes, with 16,179 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CTSO-associated genes across cancer lineages are CHEK1, CDK1, and AURKB. Each is linked with CTSO in more than 5 cancer types. Because this analysis shows association rather than direction, both CTSO-to-partner and partner-to-CTSO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTSO versus CHEK1 in GBM, with a Pearson correlation of -0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSO→partner) and Y-score (partner→CTSO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CHEK1 →	-1.118	-0.489	<.001	<.001	3	6
LUAD	CDK1 →	-1.056	-0.549	<.001	<.001	3	6
LUAD	AURKB →	-1.244	-0.621	<.001	<.001	3	6
GBM	DPYD →	+1.026	+0.330	<.001	.002	3	6
GBM	CD74 →	+1.281	+0.376	<.001	.003	3	6
GBM	MCM10 →	-1.108	-0.410	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,179 associations by consensus.

CTSO vs CHEK1 — GBM

Explore this scatter interactively →