CTSO

Across TCGA patient cohorts, CTSO mutation is significantly associated with the RNA expression of many other genes, with 2,814 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSO-associated genes across cancer lineages are KRTAP23-1, TRGJP2, and RNU6ATAC30P. Each is linked with CTSO in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSO-to-partner and partner-to-CTSO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP23-1 grouped by CTSO-low versus CTSO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSO→partner) and Y-score (partner→CTSO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KRTAP23-1 →	+0.178	+2.302	.002	.002	3	2
UCEC	TRGJP2 →	+0.575	+2.081	<.001	.002	3	2
UCEC	RNU6ATAC30P →	+0.293	+1.709	<.001	.009	3	2
UCEC	RNA5SP408 →	+0.260	+2.421	.001	.003	3	2
UCEC	RNU7-29P →	+0.160	+3.059	<.001	.005	3	2
UCEC	OSTF1P1 →	+0.185	+1.875	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,814 associations by consensus.

KRTAP23-1 by CTSO expression — UCEC

Explore this box plot interactively →