CTSO

Across TCGA cell cohorts, CTSO RNA expression is significantly associated with the go_rna of many other GO terms, with 5,422 significant associations in total. CNS shows the largest number of these associations.

The most reproducible CTSO-associated GO terms across cancer lineages are Process utilizing autophagic mechanism, Autophagy, and Macroautophagy. Each is linked with CTSO in more than 15 cancer types. Because this analysis shows association rather than direction, both CTSO-to-partner and partner-to-CTSO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Process utilizing autophagic mechanism grouped by CTSO-low versus CTSO-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSO→partner) and Y-score (partner→CTSO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Process utilizing autophagic mechanism →	+0.087	+1.336	.001	.005	3	16
STOMACH	Autophagy →	+0.087	+1.336	.001	.005	3	16
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.066	+1.096	<.001	<.001	3	15
STOMACH	Regulation of macroautophagy →	+0.086	+1.490	.001	.003	3	13
LUNG_NSCLC_LUSC	Membrane biogenesis →	+0.074	+0.954	.001	.002	3	13
OESOPHAGUS	Vesicle budding from membrane →	+0.068	+1.191	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,422 associations by consensus.

Process utilizing autophagic mechanism by CTSO expression — STOMACH

Explore this box plot interactively →