CTSO

Across TCGA cell cohorts, CTSO mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTSO-associated genes across cancer lineages are FAM71A, SLC35G3, and TBC1D21. Each is linked with CTSO in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSO-to-partner and partner-to-CTSO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71A grouped by CTSO-low versus CTSO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSO→partner) and Y-score (partner→CTSO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM71A →	+0.080	+3.453	<.001	.009	3	1
LARGE_INTESTINE	SLC35G3 →	+0.009	+3.882	<.001	.001	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TSPY2 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	QRFPR →	+1.158	+4.176	<.001	.001	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FAM71A by CTSO expression — LARGE_INTESTINE

Explore this box plot interactively →