CTSL

Across TCGA pan-cancer cohorts, CTSL mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CTSL data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CTSL mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CTSL expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

COAD, LSCC, and PDAC are the cancer types where CTSL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.875	1.000	.015	48	view →
LSCC	DFS	Median	II,III,IV	0.526	0.858	.005	18	view →
PDAC	OS	Median	IV	0.395	0.937	.026	9	view →
HNSC	DFS	Median	III,IV	0.878	0.698	.010	9	view →
LUAD	OS	Quartile	All	0.519	0.866	.012	6	view →
UCEC	DFS	Median	II,III,IV	0.518	0.882	.030	4	view →
CCRCC	DFS	Median	III,IV	0.422	0.684	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CTSL–COAD (DFS)

Open the COAD breakdown →