CTSL

Across TCGA patient cohorts, CTSL protein abundance is significantly associated with the RNA expression of many other genes, with 19,746 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CTSL-associated genes across cancer lineages are TYROBP, CCR1, and AIF1. Each is linked with CTSL in more than 9 cancer types. Because this analysis shows association rather than direction, both CTSL-to-partner and partner-to-CTSL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTSL versus TYROBP in GBM, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSL→partner) and Y-score (partner→CTSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TYROBP →	+1.110	+0.431	<.001	<.001	3	10
GBM	CCR1 →	+1.145	+0.439	<.001	<.001	3	10
GBM	AIF1 →	+0.977	+0.371	<.001	<.001	3	10
BRCA	TNFSF13B →	+0.994	+0.558	<.001	<.001	3	9
UCEC	CD86 →	+1.068	+0.505	<.001	<.001	3	9
GBM	CASP1 →	+0.907	+0.358	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,746 associations by consensus.

CTSL vs TYROBP — GBM

Explore this scatter interactively →