CTSL

Across TCGA patient cohorts, CTSL mutation is significantly associated with the RNA expression of many other genes, with 1,413 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSL-associated genes across cancer lineages are SNX3P1Y, OR4X2, and POM121C. Each is linked with CTSL in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSL-to-partner and partner-to-CTSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX3P1Y grouped by CTSL-low versus CTSL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSL→partner) and Y-score (partner→CTSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNX3P1Y →	+0.080	+4.156	<.001	.004	3	2
LUSC	OR4X2 →	+0.027	+4.853	<.001	.004	3	2
UCEC	POM121C →	+0.352	+2.831	.005	.001	3	1
UCEC	DOC2B →	-1.139	-2.662	<.001	<.001	3	1
UCEC	MAP3K4-AS1 →	+0.594	+2.343	.003	.003	3	1
UCEC	ZNHIT3 →	+0.414	+3.343	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,413 associations by consensus.

SNX3P1Y by CTSL expression — UCEC

Explore this box plot interactively →