CTSL

Across TCGA patient cohorts, CTSL mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSL-associated genes across cancer lineages are mTOR_pS2448, Rad50, and ATM. Each is linked with CTSL in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSL-to-partner and partner-to-CTSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CTSL-low versus CTSL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSL→partner) and Y-score (partner→CTSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.164	-2.565	.007	.010	3	2
UCEC	Rad50 →	-0.239	-2.308	.016	.033	3	2
UCEC	ATM →	-0.589	-2.321	.001	.006	3	2
UCEC	EGFR_pY1068 →	-0.244	-1.807	.018	.027	3	1
UCEC	MEK1 →	+0.507	+3.700	<.001	.001	3	1
UCEC	MSH2 →	-0.289	-1.807	.002	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

mTOR_pS2448 by CTSL expression — UCEC

Explore this box plot interactively →