CTSL

Across TCGA cell cohorts, CTSL RNA expression is significantly associated with the go_rna of many other GO terms, with 6,087 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CTSL-associated GO terms across cancer lineages are Macrophage apoptotic process, Elastin metabolic process, and Receptor-mediated endocytosis of virus by host cell. Each is linked with CTSL in more than 15 cancer types. Because this analysis shows association rather than direction, both CTSL-to-partner and partner-to-CTSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macrophage apoptotic process grouped by CTSL-low versus CTSL-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSL→partner) and Y-score (partner→CTSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Macrophage apoptotic process →	+0.326	+3.565	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Elastin metabolic process →	+0.387	+3.838	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Receptor-mediated endocytosis of virus by host cell →	+0.354	+3.385	<.001	<.001	3	13
STOMACH	Endocytosis involved in viral entry into host cell →	+0.174	+3.306	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Cellular response to thyroid hormone stimulus →	+0.197	+2.504	<.001	.003	3	12
BONE	Inflammatory cell apoptotic process →	+0.288	+2.545	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,087 associations by consensus.

Macrophage apoptotic process by CTSL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →