CTSK

Across TCGA pan-cancer cohorts, CTSK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CTSK data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CTSK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CTSK expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UCEC, PDAC, and GBM are the cancer types where CTSK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.399	1.000	.004	16	view →
PDAC	DFS	Quartile	III,IV	0.227	0.974	.002	15	view →
GBM	DFS	Quartile	All	0.692	0.946	.007	14	view →
HNSC	OS	Tertile	All	1.000	0.270	.021	13	view →
LSCC	DFS	Tertile	II,III,IV	0.660	0.910	.015	10	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CTSK–UCEC (DFS)

Open the UCEC breakdown →