CTSH

Across TCGA patient cohorts, CTSH RNA expression is significantly associated with the protein abundance of many other proteins, with 21,753 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CTSH-associated proteins across cancer lineages are CLIC2, VPS13C, and WIPF1. Each is linked with CTSH in more than 6 cancer types. Because this analysis shows association rather than direction, both CTSH-to-partner and partner-to-CTSH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTSH versus CLIC2 in LSCC, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSH→partner) and Y-score (partner→CTSH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLIC2 →	+0.501	+0.890	<.001	<.001	3	7
LSCC	VPS13C →	+0.301	+0.953	<.001	<.001	3	6
OV	WIPF1 →	+0.452	+0.857	<.001	<.001	3	6
LSCC	XPO5 →	-0.514	-0.667	<.001	<.001	3	6
OV	PIP4K2A →	+0.611	+1.023	<.001	<.001	3	6
COAD	NFATC2 →	+0.496	+0.422	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,753 associations by consensus.

CTSH vs CLIC2 — LSCC

Explore this scatter interactively →