CTSH

Across TCGA patient cohorts, CTSH protein abundance is significantly associated with the RNA expression of many other genes, with 15,285 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CTSH-associated genes across cancer lineages are ACSM5, NCAPG, and CENPA. Each is linked with CTSH in more than 7 cancer types. Because this analysis shows association rather than direction, both CTSH-to-partner and partner-to-CTSH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTSH versus ACSM5 in GBM, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSH→partner) and Y-score (partner→CTSH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ACSM5 →	+0.708	+0.472	<.001	<.001	3	8
GBM	NCAPG →	-0.805	-0.574	.002	<.001	3	7
BRCA	CENPA →	-1.098	-0.545	<.001	<.001	3	7
BRCA	CDC20 →	-1.523	-0.587	<.001	<.001	3	7
GBM	KIF14 →	-0.940	-0.632	.002	<.001	3	7
UCEC	NCAPH →	-1.019	-0.852	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,285 associations by consensus.

CTSH vs ACSM5 — GBM

Explore this scatter interactively →