CTSH

Across TCGA patient cohorts, CTSH mutation is significantly associated with the RNA expression of many other genes, with 2,707 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSH-associated genes across cancer lineages are MIR520H, RNU6-1242P, and RN7SKP57. Each is linked with CTSH in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSH-to-partner and partner-to-CTSH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR520H grouped by CTSH-low versus CTSH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSH→partner) and Y-score (partner→CTSH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR520H →	+0.189	+3.167	<.001	.005	3	2
UCEC	RNU6-1242P →	+0.236	+2.273	.008	.006	3	2
UCEC	RN7SKP57 →	+0.170	+1.870	.002	.008	3	2
LUAD	MTATP6P30 →	+0.064	+7.930	<.001	.008	3	2
UCEC	TBR1 →	+0.216	+3.951	.001	<.001	3	2
SKCM	NDUFA4P2 →	+0.191	+5.037	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,707 associations by consensus.

MIR520H by CTSH expression — UCEC

Explore this box plot interactively →