CTSG

Across TCGA patient cohorts, CTSG mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CTSG-associated genes across cancer lineages are MSH6, Ku80, and GSK-3a-b_pS21_S9. Each is linked with CTSG in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSG-to-partner and partner-to-CTSG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by CTSG-low versus CTSG-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSG→partner) and Y-score (partner→CTSG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MSH6 →	+0.424	+3.000	.022	.036	3	2
UCEC	Ku80 →	+0.259	+2.183	.036	.035	3	2
SKCM	GSK-3a-b_pS21_S9 →	-0.549	-3.000	.022	.036	3	1
SKCM	Cyclin-B1 →	+0.572	+2.820	.014	.035	3	1
UCEC	JNK2 →	+0.257	+3.321	.013	.010	3	1
UCEC	MEK1 →	+0.445	+3.000	.020	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MSH6 by CTSG expression — SKCM

Explore this box plot interactively →