CTSG

Across TCGA cell cohorts, CTSG RNA expression is significantly associated with the go_rna of many other GO terms, with 2,057 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CTSG-associated GO terms across cancer lineages are Neutrophil-mediated killing of fungus, Formation of translation preinitiation complex, and Photoreceptor cell maintenance. Each is linked with CTSG in more than 5 cancer types. Because this analysis shows association rather than direction, both CTSG-to-partner and partner-to-CTSG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophil-mediated killing of fungus grouped by CTSG-low versus CTSG-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSG→partner) and Y-score (partner→CTSG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Neutrophil-mediated killing of fungus →	+1.174	+3.718	<.001	<.001	3	6
SOFT_TISSUE	Formation of translation preinitiation complex →	-0.075	-0.149	<.001	.003	3	6
SOFT_TISSUE	Photoreceptor cell maintenance →	-0.052	-0.152	.001	.008	3	5
BLOOD_Leukemia	Disruption of cellular anatomical structure in another organism →	+0.800	+3.024	.001	.006	2	6
BLOOD_Leukemia	Disruption of plasma membrane integrity in another organism →	+0.800	+3.024	.001	.006	2	6
UPPER_AERODIGESTIVE_TRACT	Viral gene expression →	+0.073	+0.080	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,057 associations by consensus.

Neutrophil-mediated killing of fungus by CTSG expression — BLOOD_Leukemia

Explore this box plot interactively →