CTSF

Across TCGA pan-cancer cohorts, CTSF mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CTSF data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CTSF mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CTSF expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

UCEC, LUAD, and LSCC are the cancer types where CTSF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.467	0.946	.002	34	view →
LUAD	OS	Median	All	0.884	1.000	.002	30	view →
LSCC	DFS	Tertile	II,III,IV	0.554	0.865	.011	10	view →
CCRCC	OS	Median	IV	1.000	0.451	.016	8	view →
HNSC	DFS	Tertile	II,III,IV	0.510	0.727	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CTSF–UCEC (DFS)

Open the UCEC breakdown →