CTSF

Across TCGA patient cohorts, CTSF mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSF-associated genes across cancer lineages are PKC-delta_pS664, ASNS, and ATM. Each is linked with CTSF in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSF-to-partner and partner-to-CTSF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by CTSF-low versus CTSF-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSF→partner) and Y-score (partner→CTSF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-delta_pS664 →	-0.183	-2.991	.008	.036	3	2
UCEC	ASNS →	+0.487	+2.459	.001	.019	3	2
UCEC	ATM →	-0.753	-2.446	<.001	.018	3	2
UCEC	cIAP →	+0.115	+2.179	.049	.034	3	2
UCEC	4E-BP1 →	+0.514	+2.906	<.001	.001	3	2
COAD	PKC-b-II_pS660 →	-0.503	-2.991	.006	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PKC-delta_pS664 by CTSF expression — COAD

Explore this box plot interactively →