Across TCGA patient cohorts, CTSE protein abundance is significantly associated with the RNA expression of many other genes, with 9,868 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CTSE-associated genes across cancer lineages are SLC1A1, MTARC2, and GNG4. Each is linked with CTSE in more than 3 cancer types. Because this analysis shows association rather than direction, both CTSE-to-partner and partner-to-CTSE results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSE→partner) and Y-score (partner→CTSE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC1A1 →	+1.591	+2.046	<.001	<.001	3	4
COAD	MTARC2 →	+0.700	+1.392	.001	<.001	3	4
COAD	GNG4 →	-2.334	-1.561	<.001	.001	3	4
COAD	MMP28 →	+1.230	+1.811	.002	.003	3	4
UCEC	CCDC150 →	-0.932	-0.756	<.001	.008	3	4
LUAD	SLC26A9 →	+1.620	+1.004	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,868 associations by consensus.

Exploration

CTSE survival (RNA) · tumor vs normal (RNA) · all CTSE data types