Across TCGA patient cohorts, CTSE mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSE-associated genes across cancer lineages are Caspase-8, Notch1, and p27_pT198. Each is linked with CTSE in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSE-to-partner and partner-to-CTSE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSE→partner) and Y-score (partner→CTSE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.252	-3.558	.015	.002	3	2
UCEC	Notch1 →	+0.150	+1.884	.010	.030	3	1
UCEC	p27_pT198 →	+0.099	+1.807	.024	.027	3	1
UCEC	p62 Lck ligand →	+0.480	+3.321	<.001	.009	3	1
UCEC	Paxillin →	+0.223	+2.321	.036	.006	3	1
UCEC	PREX1 →	-0.223	-2.321	.049	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

CTSE survival (RNA) · tumor vs normal (RNA) · all CTSE data types