CTSB

Across TCGA pan-cancer cohorts, CTSB mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CTSB data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CTSB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CTSB expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

COAD, HNSC, and CCRCC are the cancer types where CTSB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.887	1.000	.022	54	view →
HNSC	DFS	Quartile	All	0.868	1.000	.007	15	view →
CCRCC	OS	Median	All	1.000	0.911	.023	13	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
GBM	OS	Tertile	All	0.742	0.966	.008	5	view →
OV	DFS	Median	All	0.709	1.000	.047	4	view →
LSCC	OS	Tertile	All	0.736	1.000	.035	4	view →
LUAD	DFS	Quartile	II,III,IV	0.883	0.429	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CTSB–COAD (DFS)

Open the COAD breakdown →