CTSA

Across TCGA patient cohorts, CTSA RNA expression is significantly associated with the protein abundance of many other proteins, with 14,110 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CTSA-associated proteins across cancer lineages are PLOD3, ACOT8, and PLOD1. Each is linked with CTSA in more than 6 cancer types. Because this analysis shows association rather than direction, both CTSA-to-partner and partner-to-CTSA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTSA versus PLOD3 in GBM, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSA→partner) and Y-score (partner→CTSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLOD3 →	+0.458	+0.327	<.001	<.001	3	7
COAD	ACOT8 →	+0.388	+0.843	<.001	<.001	3	7
OV	PLOD1 →	+0.520	+0.595	<.001	.001	3	6
LSCC	RASSF4 →	+0.541	+0.399	<.001	<.001	3	5
LUAD	PLAUR →	+0.473	+0.545	<.001	<.001	3	5
GBM	COLGALT1 →	+0.511	+0.328	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,110 associations by consensus.

CTSA vs PLOD3 — GBM

Explore this scatter interactively →