CTSA

Across TCGA patient cohorts, CTSA protein abundance is significantly associated with the RNA expression of many other genes, with 16,351 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CTSA-associated genes across cancer lineages are EIF4B, SCAPER, and RPL4. Each is linked with CTSA in more than 6 cancer types. Because this analysis shows association rather than direction, both CTSA-to-partner and partner-to-CTSA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTSA versus EIF4B in UCEC, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSA→partner) and Y-score (partner→CTSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF4B →	-0.900	-0.442	<.001	<.001	3	7
LSCC	SCAPER →	-0.528	-0.294	<.001	<.001	3	6
HNSC	RPL4 →	-1.089	-0.246	<.001	<.001	3	6
CCRCC	KMO →	+1.071	+0.293	.007	.005	2	7
HNSC	RPL5 →	-0.772	-0.169	.002	<.001	3	6
LSCC	DOK3 →	+0.572	+0.285	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,351 associations by consensus.

CTSA vs EIF4B — UCEC

Explore this scatter interactively →