CTSA

Across TCGA patient cohorts, CTSA mutation is significantly associated with the RNA expression of many other genes, with 1,300 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSA-associated genes across cancer lineages are TEMN3-AS1, MIR132, and TRAJ22. Each is linked with CTSA in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSA-to-partner and partner-to-CTSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEMN3-AS1 grouped by CTSA-low versus CTSA-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSA→partner) and Y-score (partner→CTSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TEMN3-AS1 →	+0.337	+5.337	<.001	.006	3	2
UCEC	MIR132 →	+0.247	+2.771	<.001	.003	3	2
UCEC	TRAJ22 →	+0.502	+1.913	.003	.003	3	2
UCEC	RBMX2P3 →	+0.153	+2.153	.002	.004	3	2
UCEC	MAGI2-AS2 →	+0.096	+3.335	<.001	<.001	3	2
UCEC	RNA5SP420 →	+0.800	+2.677	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,300 associations by consensus.

TEMN3-AS1 by CTSA expression — LUSC

Explore this box plot interactively →