CTSA

Across TCGA patient cohorts, CTSA mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSA-associated genes across cancer lineages are p38-MAPK_pT180_Y182, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with CTSA in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSA-to-partner and partner-to-CTSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by CTSA-low versus CTSA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSA→partner) and Y-score (partner→CTSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.587	-3.584	.002	.002	3	2
UCEC	EGFR_pY1068 →	-0.335	-3.459	.002	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.214	-2.459	.003	.019	3	1
UCEC	Ku80 →	+0.257	+1.598	.012	.044	3	1
UCEC	Lck →	+0.174	+2.115	.047	.019	3	1
UCEC	MSH2 →	-0.346	-2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

p38-MAPK_pT180_Y182 by CTSA expression — UCEC

Explore this box plot interactively →