CTSA

Across TCGA cell cohorts, CTSA mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTSA-associated genes across cancer lineages are LIM2, KIR2DL1, and OPCML. Each is linked with CTSA in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSA-to-partner and partner-to-CTSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIM2 grouped by CTSA-low versus CTSA-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSA→partner) and Y-score (partner→CTSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LIM2 →	+0.049	+5.614	<.001	.002	3	1
PANCREAS	KIR2DL1 →	+0.016	+5.000	<.001	.006	3	1
PANCREAS	OPCML →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	KRTAP5-3 →	+0.021	+5.000	.004	.006	3	1
PANCREAS	SLC22A12 →	+0.006	+5.614	<.001	.002	3	1
STOMACH	KRTAP2-2 →	+0.128	+3.209	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

LIM2 by CTSA expression — PANCREAS

Explore this box plot interactively →